[Content and distribution of iodine, chlorine and bromine in normal and pathologically changed thyroid gland tissue]. 1984

A F Malenchenko, and E P Demidchik, and V N Tadeush

The neutron-activation method was used to study the content and distribution of iodine, chlorine and bromine in 53 thyroid glands removed from patients during operation and 8 thyroid glands from persons who died in accidents. It has been shown that a statistically significant decrease in the iodine concentration occurs in struma maligna, Hashimoto's disease and a mixed form of endemic euthyroid goiter. The chlorine content did not change. The bromine concentration in all form of thyroid pathology was raised. The highest bromine content was found in "cold" forms--struma maligna, and it exceeded almost by 50 times the rates in the control group. Autoradiographic studies made it possible to establish some peculiarities in the distribution of radioactive and stable iodine in the thyroid tissue depending on its morphofunctional condition. Radioactive iodine gradients in the normal tissue did not exceed 7, in mixed (parenchymatous) forms of the goiter 42.5. The distribution of stable iodine is characterized by a high irregularity. The aplastic forms of struma maligna least of all accumulate and contain stable iodine, their structure being characterized by functional monotony.

UI MeSH Term Description Entries
D007455 Iodine A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically. Iodine-127,Iodine 127
D009501 Neutron Activation Analysis Activation analysis in which the specimen is bombarded with neutrons. Identification is made by measuring the resulting radioisotopes. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Activation Analysis, Neutron,Analysis, Neutron Activation,Activation Analyses, Neutron,Analyses, Neutron Activation,Neutron Activation Analyses
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001966 Bromine A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested. Bromine-79,Bromine 79
D002713 Chlorine An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family. Chlorine Gas,Chlorine-35,Cl2 Gas,Chlorine 35,Gas, Chlorine,Gas, Cl2
D006043 Goiter, Endemic A form of IODINE deficiency disorders characterized by an enlargement of the THYROID GLAND in a significantly large fraction of a POPULATION GROUP. Endemic goiter is common in mountainous and iodine-deficient areas of the world where the DIET contains insufficient amount of iodine. Endemic Goiter,Endemic Goiters,Goiters, Endemic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013959 Thyroid Diseases Pathological processes involving the THYROID GLAND. Disease, Thyroid,Diseases, Thyroid,Thyroid Disease
D013961 Thyroid Gland A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively. Thyroid,Gland, Thyroid,Glands, Thyroid,Thyroid Glands,Thyroids
D013964 Thyroid Neoplasms Tumors or cancer of the THYROID GLAND. Cancer of Thyroid,Thyroid Cancer,Cancer of the Thyroid,Neoplasms, Thyroid,Thyroid Adenoma,Thyroid Carcinoma,Adenoma, Thyroid,Adenomas, Thyroid,Cancer, Thyroid,Cancers, Thyroid,Carcinoma, Thyroid,Carcinomas, Thyroid,Neoplasm, Thyroid,Thyroid Adenomas,Thyroid Cancers,Thyroid Carcinomas,Thyroid Neoplasm

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