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The effect of in vivo hepatic iron overload, induced by two different amounts of iron, on the energy-transducing efficiency of the mitochondrial membrane has been examined. It has been found that when the epatic iron concentration is up to a threshold value mitochondria present an anomalous membrane potential. Addition of oligomycin fully restitutes it. A low content of intramitochondrial K+ is connected with this pathological condition. A relative lack of antioxidant capability is parallely exhibited by these mitochondria. A possible involvement of lipid peroxidation process in vivo in causing the membrane potential drop and the net efflux of intramitochondrial K+ is suggested.
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
October 1993,
Gastroenterology,
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
January 1990,
Hepatology (Baltimore, Md.),
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
January 1985,
Hepatology (Baltimore, Md.),
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
June 1986,
Gastroenterology,
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
March 1983,
The Journal of clinical investigation,
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
January 1983,
Transactions of the Association of American Physicians,
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
March 1989,
Hepatology (Baltimore, Md.),
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
July 2024,
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS),
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
January 1973,
Postgraduate medicine,
A Masini, and
T Trenti, and
E Ventura, and
D Ceccarelli-Stanzani, and
U Muscatello
January 1995,
Ryoikibetsu shokogun shirizu,
