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Thirty healthy women in active labour received an intrathecal injection of morphine 0.5 mg (n = 12) or 1 mg (n = 18) in 7.5% dextrose. Both doses provided excellent analgesia for labour, 93% of patients obtaining at least 50% pain relief. Analgesia began 15-60 min after injection and did not decrease until 6-8 h after injection. Analgesia was satisfactory until distension of the perineum, either by forceps or the infant's head. The intrathecal injection of morphine did not adversely affect the condition of the infant. Eighty per cent of patients developed pruritus; 53%, nausea or vomiting, or both; 43%, urinary retention; and 43%, drowsiness. These side effects were decreased by naloxone, which did not affect the degree of analgesia. There was no significant depression of ventilation in any patient. These results suggest that morphine 0.5 mg or 1 mg, administered intrathecally, effectively decreases the pain of labour, and that i.v. administration of naloxone can alleviate the common side effects.
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
June 1984,
Asia-Oceania journal of obstetrics and gynaecology,
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
February 1984,
British journal of anaesthesia,
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
January 1983,
The Canadian nurse,
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
July 1987,
European journal of obstetrics, gynecology, and reproductive biology,
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
December 1988,
Ugeskrift for laeger,
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
February 2001,
British journal of anaesthesia,
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
September 1992,
Masui. The Japanese journal of anesthesiology,
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
February 1988,
Pain,
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
April 1995,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
T K Abboud, and
S M Shnider, and
P A Dailey, and
J A Raya, and
F Sarkis, and
N M Grobler, and
S Sadri, and
S S Khoo, and
B DeSousa, and
C L Baysinger
January 1987,
Revista espanola de anestesiologia y reanimacion,
