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The synthetic nonapeptide DSIP was studied in rabbits and cats under normal conditions and under conditions of disturbed sleep. In other experiments, the effect of the oligopeptide on withdrawal jumping provoked by naloxone in morphine-dependent mice was studied. In rabbits, DSIP at 25 micrograms X kg-1 i.v. and 1 mg X kg-1 s.c. augmented spindle-dominated, light nonREM sleep and prevented hyposomnia after a stressful situation. In cats, 25 micrograms X kg-1 i.v. and 100 micrograms X kg-1 s.c. preferentially augmented REM sleep and abolished the sleep suppressant effect of morphine. In morphine-dependent mice, 25.5 micrograms X kg-1 i.v. as well as doses beyond 85 micrograms X kg-1 s.c. attenuated naloxone-induced withdrawal jumping. In most experimental situations, indications for bell-shaped dose-response curves of DSIP were found.
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
January 1984,
Neuroscience and biobehavioral reviews,
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
January 1986,
Peptides,
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
January 2014,
Bioorganicheskaia khimiia,
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
April 2006,
Journal of neurochemistry,
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
August 1981,
International journal of clinical pharmacology, therapy, and toxicology,
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
July 1979,
Neuroscience letters,
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
April 1986,
Pharmacology, biochemistry, and behavior,
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
December 1992,
Sleep,
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
January 1984,
European neurology,
R Scherschlicht, and
L Aeppli, and
P Polc, and
W Haefely
February 1983,
Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences,
