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The cytochemical section-bioassay of thyroid stimulating activity is described. Plasma of thyrotoxic patients as well as those on block-replace treatment with carbimazole and thyroid hormones was used. Linear parallel responses were obtained over the range 1.5 X 10(-7) to 1.5 X 10(-5) mU/1 MRC LATS-B standard. The index of precision was 0.19 +/- 0.028. The fiducial limits (p=0.95) of a sample tested on ten separate occasions were 52-192%. Specificity was investigated using time course studies, and the effect of anti-TSH or anti-IgG antisera. No effect of methimazole or a variety of other drugs was detected. The assay is accordingly validated for measurement of TSI in patients both untreated and on block-replace therapy.
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
January 1980,
Journal of immunoassay,
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
October 1979,
The Journal of clinical endocrinology and metabolism,
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
August 1974,
Lancet (London, England),
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
June 1986,
Endocrinologia japonica,
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
March 1977,
Clinical endocrinology,
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
February 1982,
The Journal of clinical endocrinology and metabolism,
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
May 1979,
The Journal of endocrinology,
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
December 2010,
Clinical and experimental immunology,
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
January 1983,
Acta endocrinologica. Supplementum,
M G Prentice, and
J Alaghband-Zadeh, and
P H Wise
October 1986,
Medicina clinica,
