Biomaterial Database

Pulmonary shunting and lung volume during hypotension induced with trimetaphan. 1978

D S Skene, and S F Sullivan, and R W Patterson

In 10 dogs anaesthetized with pentobarbitone mean Pa02 decreased from the control value of 13.5 kPa to 10.2 kPa, cardiac output decreased by 33%, and right-to-left shunt doubled during hypotension induced with trimetaphan. There was no signficant change in functional residual capacity during the period of hypotension or recovery. The hypoxaemia resulted from an increase in ventilation/perfusion inequality, with a decrease in arterial saturation consequent upon a decrease in cardiac output with a constant shunt. During the recovery period, right-to-left shunting remained greater than the values obtained before induction of hypotension.

UI	MeSH Term	Description	Entries
D007023	Hypotension, Controlled	Procedure in which arterial blood pressure is intentionally reduced in order to control blood loss during surgery. This procedure is performed either pharmacologically or by pre-surgical removal of blood.	Controlled Hypotension,Hypotension, Induced,Induced Hypotension
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014294	Trimethaphan	A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.	Thimethaphan,Trimetaphan