-transparent.png){kind=logo}
1 Log dose-responses for the loop diuretics bumetanide and frusemide in healthy subjects deviated significantly from parallelism as regards urine volume and sodium excretion. Ignoring the nonparallelism the best estimate of natriuretic potency (bumetanide: frusemide) was 46:1 in the bumetanide dose range 0.5-2 mg. 2 For a given natriuresis the urinary potassium excretion following bumetanide was significantly lower than that for frusemide within this dose range. 3 The data illustrate the limitations of studies comparing diuretics at a single dose level. Extrapolation of the observed log dose-response curves provides one possible explanation for the relative potency (bumetanide: frusemide) of 20:1 reported when the drugs are used at high dosage in patients with renal failure.
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
April 1975,
Arzneimittel-Forschung,
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
January 1977,
Current medical research and opinion,
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
April 1986,
British journal of clinical pharmacology,
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
January 1975,
Postgraduate medical journal,
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
April 1976,
Lancet (London, England),
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
August 1976,
British journal of clinical pharmacology,
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
March 1989,
British journal of clinical pharmacology,
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
October 1988,
The British journal of clinical practice,
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
November 1979,
British journal of pharmacology,
L E Ramsay, and
G T McInnes, and
J Hettiarachchi, and
J Shelton, and
P Scott
February 1981,
Postgraduate medical journal,
