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1 Hepatic blood flow was determined before and during (+)- and (+/-)-propranolol plasma concentration plateaus in 19 patients with suspected renal hypertension and normal liver function. 2 Hepatic blood flow significantly decreased (P less than 0.001) during (+/-)-propranolol administration and remained unchanged during (+)-propranolol administration. 3 Hepatic extraction ratio was 74 +/- 1% (+/-)-propranolol and 79 +/- 2% for (+)-propranolol. 4 Total propranolol clearances were determined during the steady-state achieved by a constant infusion. A highly significant positive relationship was observed (r = +0.86; P less than 0.01) between hepatic blood flow and (+)-propranolol clearance. The slope of the curve was 1.05 +/- 0.27. 5 The result implies that the total clearance of (+)-propranolol constitutes an accurate estimation of basal hepatic blood flow in subjects with normal liver function.
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
November 1945,
The Journal of clinical investigation,
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
November 1945,
The Journal of clinical investigation,
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
April 1986,
Surgery,
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
December 1973,
The Journal of pharmacology and experimental therapeutics,
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
April 1960,
The American journal of physiology,
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
January 1960,
Methods in medical research,
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
June 1987,
Journal of hepatology,
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
January 1989,
Gastroenterology,
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
June 1973,
British journal of pharmacology,
Y A Weiss, and
M E Safar, and
J P Lehner, and
J A Levenson, and
A Simon, and
J M Alexandre
January 1994,
Chirality,
