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The Lipoprotein profile of 24 patients with endometriosis was determined before, during and after the treatment with the two steroid hormones Lynestrenol (10 mg/day) and Danazol (600-800 mg/day). The total cholesterol triglycerides, beta-, prebeta-, and Alphalipo -protein bound to cholesterol were determined. Both hormones cause a marked lowering of the Alpha-Lp-cholesterin. In addition, the beta-LP-cholesterin was elevated and the beta-alpha-LP-ratio was elevated. In the dosage used by us, Lynestrenol showed less effect on the Lipoprotein profile. Danazol caused changed in the beta- and alpha-lipoprotein pattern of highly pathological atherogenic types. The total cholesterol was not influenced. Since women in the fertile age group will suffer a higher risk of arteriosclerosis from an elevation of the beta-LP-cholesterin, the treatment with Danazol calls for a sophisticated monitoring of the lipid metabolism and care in the indication for long term treatment with Danazol or with Lynestrenol.
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
November 1984,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
November 1980,
Clinical pharmacology and therapeutics,
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
January 1984,
Acta obstetricia et gynecologica Scandinavica. Supplement,
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
February 1976,
The Journal of the Maine Medical Association,
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
June 1989,
American journal of obstetrics and gynecology,
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
January 1963,
Bulletin de la Societe royale belge de gynecologie et d'obstetrique,
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
January 1963,
Annales chirurgiae et gynaecologiae Fenniae,
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
January 1975,
American journal of obstetrics and gynecology,
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
August 1985,
Fertility and sterility,
A T Teichmann, and
H Wieland, and
P Cremer, and
W Kuhn, and
D Seidel
January 1982,
Progress in clinical and biological research,
