-transparent.png){kind=logo}
A 15-year-old female experienced two systemic infections with N.meningitidis (group C and B) within a two months period. Classical as well as alternative pathway CH50 determinations on the patients serum showed no lysis. All individual complement factor concentrations, except for C3, were found to be within the reference area. Crossed immunoelectrophoretic analysis of C3 revealed no demonstrable native C3. The patient had normal levels of C3c and a markedly elevated C3d concentration. Serum from the patient was found to convert all native C3 in normal sera within 10 minutes at 37 degrees C. The active converting principle, present in the IgG fraction activated C3 in C4-depleted serum, and had a dose dependent stabilizing effect on the EA-C3bBb complex. The isolated factor showing the characteristics of C3 nephritic factor (C3 NeF), was unchanged in the patients serum over a ten months observation period. Circulating immune complexes (IC) could not be demonstrated by a C1q-dependent assay but the patients capacity to solubilize preformed IC in vitro was virtually abolished. The patient had no signs of renal disease or lipodystrophy.
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
May 1983,
The New England journal of medicine,
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
October 1984,
Scandinavian journal of immunology,
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
October 2008,
Clinical immunology (Orlando, Fla.),
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
January 2014,
Pediatric nephrology (Berlin, Germany),
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
April 1986,
Journal of clinical & laboratory immunology,
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
July 1979,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
August 2016,
Clinical immunology (Orlando, Fla.),
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
July 1978,
Casopis lekaru ceskych,
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
July 1977,
The New England journal of medicine,
B Teisner, and
P Elling, and
S E Svehag, and
L Poulsen, and
L U Lamm, and
A Sjöholm
January 1995,
Nephron,
