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Between May 1976 and September 1977, 51 patients with severe psoriasis were treated with orally administered 8-methoxypsoralen followed by exposure to high-intensity long-wavelength ultraviolet radiation. Clearing of psoriasis occurred in 40 patients (78%) and marked improvement in 5 (10%). Of the remaining patients three (6%), who had generalized erythroderma, failed to respond to this therapy. The mean number of treatments required for clearing was 37.5. No serious side effects were noted clinically, by ophthalmologic examination or by laboratory testing. This therapy has some advantages over conventional types of treatment now used for severe psoriasis, but also has limitations. It appears to be an effective method of treatment for ambulatory patients. Further long-term follow-up studies are required to evaluate its side effects.
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
March 1979,
The British journal of dermatology,
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
September 1976,
Ugeskrift for laeger,
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
January 1992,
Blood cells,
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
July 1989,
Blood,
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
August 1981,
The Journal of investigative dermatology,
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
July 1976,
Nederlands tijdschrift voor geneeskunde,
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
November 1993,
Photochemistry and photobiology,
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
April 1978,
Minerva medica,
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
August 1976,
Dermatologische Monatschrift,
G A Wasserman, and
M W Llewellyn, and
C A Ramsay, and
H F Haberman
January 1978,
Ceskoslovenska dermatologie,
