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Phase II studies utilizing VP-16-213 in the treatment of 56 patients with malignant lymphoma and 29 patients with malignant melanoma were carried out by the Southwest Oncology Group. All patients had received extensive prior therapy. The initial dose of VP-16-213 administered was 45 mg/m2 by iv infusion over 30-60 minutes on Days 1-5 every 3 weeks but, because, of severe myelosuppression in the lymphoma group, the dose was subsequently reduced to 35 mg/m2. Only three partial regressions lasting 6, 2, and 1 months were noted in 17 patients with Hodgkin's disease. No favorable responses were noted in 35 patients with non-Hodgkin's lymphoma including 16 with the diffuse histiocytic type. No responses were noted in patients with melanoma. The major toxic effect was myelosuppression. VP-16-213 appears to lack significant effectiveness in these previously treated disease.
J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
May 1985,
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J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
June 1979,
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J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
November 1976,
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J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
September 1984,
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J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
May 1984,
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J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
January 1979,
Cancer chemotherapy and pharmacology,
J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
March 1975,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
October 1986,
Cancer biochemistry biophysics,
J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
September 1986,
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J W Cecil, and
J M Quagliana, and
C A Coltman, and
M Al-Sarraf, and
T Thigpen, and
C W Groppe
February 1976,
Postgraduate medical journal,
