BIOMAT Database Logo BIOMAT Database Logo

Granulocytes and cultured human fibroblasts express common acute lymphoblastic leukemia-associated antigens. 1983

M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen

We have investigated the expression of the common acute lymphoblastic leukemia antigen (cALLA) by nonlymphoid cells, using a new murine monoclonal antibody (designated 24.1), specific for cALLA. This antibody completely blocks the binding of monoclonal anti-cALLA antibody J-5. Furthermore, antibody 24.1 binds to cALLA with greater affinity and induces a greater degree of antigenic modulation than antibody J-5. With antibody 24.1, we have demonstrated that normal cultured marrow and skin fibroblasts and mature granulocytes express cALLA. By immune precipitation and polyacrylamide gel electrophoresis, cALLA from fibroblasts has a slightly lower molecular weight and cALLA from granulocytes a slightly higher molecular weight than cALLA from cultured human leukemic cell lines. Quantitative studies indicate, however, that cALLA expression is approximately 3-fold and 20-fold lower, respectively, on normal granulocytes and skin fibroblasts than on NALM-6 cells. cALLA may be expressed by cells with widespread distribution in multiple organ systems. These findings emphasize that differentiation markers that appear to be tumor or tissue specific may be found on cells of diverse origin.

UI MeSH Term Description Entries
D007945 Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts. Leukemia, Lymphocytic,Lymphocytic Leukemia,Lymphoid Leukemia,Leukemias, Lymphocytic,Leukemias, Lymphoid,Lymphocytic Leukemias,Lymphoid Leukemias
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008970 Molecular Weight The sum of the weight of all the atoms in a molecule. Molecular Weights,Weight, Molecular,Weights, Molecular
D011233 Precipitin Tests Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate. Precipitin Test,Test, Precipitin,Tests, Precipitin
D001853 Bone Marrow The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D005347 Fibroblasts Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. Fibroblast
D006098 Granulocytes Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS. Granulocyte
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000911 Antibodies, Monoclonal Antibodies produced by a single clone of cells. Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal

Related Publications

M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen.
March 1983, The Journal of experimental medicine,
M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
Nonhuman primates express human leukemia-associated antigens.
November 1984, Blood,
M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
Acute lymphoblastic leukemia-derived dendritic cells express tumor associated antigens: PNPT1, PMPCB, RHAMM, BSG and ERCC1.
January 2009, Neoplasma,
M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
New antigenic determinant common to human thymus leukaemia-associated antigens and common acute lymphoblastic leukaemia antigen.
September 1981, Clinical and experimental immunology,
M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
Cultured human decidual stromal cells express antigens associated with hematopoietic cells.
February 1996, Journal of reproductive immunology,
M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
Expression of HLA-DR and common acute lymphoblastic leukemia antigens on glioma cells.
April 1982, European journal of immunology,
M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
Cultured marrow stromal cells express common acute lymphoblastic leukaemia antigen (CALLA): implications for marrow transplantation.
December 1983, British journal of haematology,
M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
[The presence of CALLA (common acute lymphoblastic leukemia antigens) and B-cell differentiation antigens in lymphocytic lymphoma].
September 1984, Polski tygodnik lekarski (Warsaw, Poland : 1960),
M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
Expression of B-cell-associated antigens on acute lymphoblastic leukemia cells.
January 1992, Pediatric hematology and oncology,
M P Braun, and P J Martin, and J A Ledbetter, and J A Hansen
Purification and characterization of fetal hematopoietic cells that express the common acute lymphoblastic leukemia antigen (CALLA).
January 1983, The Journal of experimental medicine,
Copied contents to your clipboard!