-transparent.png){kind=logo}
Three distinct transforming genes present in human tumor cell lines are all related to the viral oncogenes of Harvey and Kirsten murine sarcoma viruses, designated v-H-ras and v-K-ras, respectively. The transforming gene of a bladder carcinoma cell line has been shown to be a human homolog to v-H-ras [Parada, L. F., Tabin, C. J., Shih, C. & Weinberg, R. A. (1982) Nature (London) 297, 474-478; Santos, E., Tronick, S. R., Aaronson, S. A., Pulciani, S. & Barbacid, M. (1982) Nature (London) 298, 343-347]. The transforming gene common to one colon (SK-CO-1) and two lung carcinoma (SK-LU-1 and Calu-1) cell lines is the same human homolog of v-K-ras as is the transforming gene previously identified in a lung carcinoma cell line Lx-1 [Der, C. J., Krontiris, T. G. & Cooper, G. M. (1982) Proc. Natl. Acad. Sci. USA 79, 3637-3640]. The transforming gene of SK-N-SH neuroblastoma cells is weakly homologous to both v-H-ras and v-K-ras. NIH 3T3 cells transformed with the SK-N-SH transforming gene contain increased levels of a protein serologically and structurally related to the protein products of the v-H-ras and v-K-ras genes. Therefore, it represents a third member of the ras gene family, which we have called N-ras. Based on the homology with the v-ras genes, we have established the orientation of transcription and approximate coding regions of the cloned human K-ras and N-ras genes.
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
January 1987,
Cell,
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
August 1983,
Proceedings of the National Academy of Sciences of the United States of America,
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
January 1985,
British journal of cancer,
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
January 1987,
Virologie,
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
January 1990,
Cancer cells (Cold Spring Harbor, N.Y. : 1989),
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
July 1981,
Science (New York, N.Y.),
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
August 1987,
Science (New York, N.Y.),
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
January 1984,
Cancer investigation,
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
December 1988,
Journal of virology,
K Shimizu, and
M Goldfarb, and
Y Suard, and
M Perucho, and
Y Li, and
T Kamata, and
J Feramisco, and
E Stavnezer, and
J Fogh, and
M H Wigler
June 1982,
Proceedings of the National Academy of Sciences of the United States of America,
