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A total of 250 individuals belonging to 19 different families, identified through established propositi were simultaneously screened for hereditary spherocytosis (SPH), using stringent criteria, and 27 well-known polymorphic genetic marker systems. The segregation analysis indicated that the pattern of inheritance of SPH in these families, being autosomal and dominant, had a 100% penetrance. A statistical analysis, using the LIPED computer program of Ott (1974), revealed the absence of close linkage between SPH and ABO, ACP1, ADA, AK1, C3, DIA2, ESD, FY, GC, GLO1, GM, GPT1, HLA, HPA, JK, K, KM, MNS, P, PGD, PGM1, PGP, PI, and RH. Since an earlier study by other investigators had convincingly suggested a linkage between SPH and GM, we subjected the data to further analysis and found no significant heterogeneity in our recombination values of linkage between SPH and GM, or any of the other informative loci.
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
September 1979,
American journal of human genetics,
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
January 1984,
American journal of nephrology,
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
January 1977,
Vox sanguinis,
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
March 1988,
Journal of medical genetics,
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
January 1977,
Lancet (London, England),
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
April 1986,
Human genetics,
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
February 1977,
Tissue antigens,
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
December 1979,
Transplantation proceedings,
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
November 1978,
Blood,
B M de Jongh, and
H A Blacklock, and
P Reekers, and
W S Volkers, and
P Meera Khan, and
L F Bernini, and
L E Nijenhuis, and
E van Loghem, and
G M Schreuder, and
J J van Rood
September 1990,
Lancet (London, England),
