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Tissue concentrations of cefmetazole (CMZ) in rabbits were 17--49% of the blood levels at the corresponding time. Transfer pattern of CMZ was very similar to the pattern of the blood level, suggesting to be supposable the tissue concentration of CMZ. The clinical trial was studied concentrating on the observation of side effects and laboratory findings, especially the change of transaminase after anesthesia with GOF (gas-oxygen-fluothane). Four cases, who had anethesia with GOF, revealed the elevation of transaminase.
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