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An intraoral fluoride releasing device designed to provide continual topical fluoride therapy for the prevention of dental caries was found to be effective in inhibiting caries in the rat model. Animals fitted with an intraoral device that released approximately 0.15 mg of fluoride per day developed 63% fewer carious enamel areas than animals receiving no treatment. Fluoridated drinking water (10 ppm) produced a 25% reduction in carious enamel areas. The fluoride-releasing device was more effective than ad libitum fluoridated drinking water in inhibiting caries on the approximal and sulcal surfaces. These results agree with the hypothesis that the continual presence of fluoride in oral fluids enhances the cariostatic effect of fluoride and, when combined with the results of earlier primate and human trials of the intraoral fluoride-releasing device, suggest that this fluoride delivery system can be developed into an effective anticaries agent.
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
January 1991,
Caries research,
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
November 1995,
Advances in dental research,
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
October 1993,
American journal of dentistry,
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
September 1986,
Journal of the American Dental Association (1939),
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
January 2001,
Caries research,
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
January 2000,
Journal of periodontology,
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
January 1998,
Journal of dentistry,
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
March 2016,
Dental materials : official publication of the Academy of Dental Materials,
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
September 1993,
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology,
D B Mirth, and
D D Adderly, and
S M Amsbaugh, and
E Monell-Torrens, and
S H Li, and
W H Bowen
January 1994,
Caries research,
