-transparent.png){kind=logo}
A series of nine consecutive patients with multiple myeloma and renal failure is presented. All patients were treated with urinary alkalinisation with sodium bicarbonate and/or acetazolamide, diuresis with saline, mannitol and/or furosemide, pulse melphalan and prednisone and, where indicated, allopurinol and aluminium hydroxide. A substantial and sustained improvement in renal function has been achieved in all nine patients. Of five patients with a urea more than 25 mmol/L at presentation, the median survival to date is 64 weeks. Of these patients only one has died --not from renal failure but pneumonia, eighteen months after presentation. The others are alive and well. The results confirm the effectiveness of these measures in both improving renal function and prolonging survival, and suggest a more optimistic prognosis for patients with multiple myeloma and renal failure.
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
June 1994,
Clinical and laboratory haematology,
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
March 1959,
The American journal of medicine,
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
February 2008,
Clinical lymphoma & myeloma,
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
March 1980,
Medicina clinica,
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
June 2009,
Vnitrni lekarstvi,
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
January 2020,
Vnitrni lekarstvi,
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
October 2010,
Clinical nephrology,
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
November 2011,
Revista medica de Chile,
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
June 1999,
Blood reviews,
D C Harris, and
L S Ibels, and
R B Ravich, and
J P Isbister, and
J V Wells
January 2015,
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia,
