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A significant reduction of plasma fibronectin levels was found in polycythaemia vera and myelofibrosis, the lowest levels being found in patients with marked splenomegaly. Plasma fibronectin concentration was normal in essential thrombocythaemia, and only modest reduction was seen in chronic granulocytic leukaemia in either controlled chronic phase or blast cell crisis. In a patient with myelofibrosis, the plasma fibronectin rose from less than 100 mg/l to 177 mg/l after splenectomy. Possible explanations include increased consumption of plasma fibronectin in the expanded mononuclear phagocyte system present in the liver and spleen, reduced hepatic synthesis, and the clearance of circulating immune complexes. Low plasma fibronectin concentrations may increase susceptibility to infection.
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
September 1987,
Scandinavian journal of clinical and laboratory investigation,
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
July 1987,
European journal of haematology,
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
January 1976,
Haematologia,
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
December 1987,
Journal of clinical pathology,
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
November 1974,
British medical journal,
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
May 1990,
The Journal of the Association of Physicians of India,
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
January 1970,
Beitrage zur Pathologie,
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
May 1964,
Lancet (London, England),
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
July 1974,
The Medical journal of Australia,
D R Norfolk, and
M Bowen, and
B E Roberts, and
J A Child
November 1969,
Helvetica medica acta,
