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A study was carried out in 9 women volunteers to investigate the centron of 0.75 mg lynestrenol plus 0.0375 mg ethinyl oestradiol given for 22 days per cycle over a period of 6 cycles. The results of assessments of a number of hormonal, vaginal and cervical parameters showed that this combination has a two-fold effect: a central effect on the pituitary and a peripheral effect on the ovaries and on endometrial development. The findings of an effect on cervical mucus, as with higher dose combinations, were not sufficiently consistent to warrant a claim for a cervical barrier. The preparation appeared to be well tolerated but there was a high incidence of irregular bleeding in the first treatment cycle. In most of the women, however, this had corrected itself by the second cycle.
H Kallio, and
K Rhen
November 1969,
Minnesota medicine,
H Kallio, and
K Rhen
January 1983,
The Journal of reproductive medicine,
H Kallio, and
K Rhen
November 1976,
Therapie der Gegenwart,
H Kallio, and
K Rhen
October 1968,
Canadian family physician Medecin de famille canadien,
H Kallio, and
K Rhen
January 1977,
Current medical research and opinion,
H Kallio, and
K Rhen
November 1995,
Clinical pharmacology and therapeutics,
H Kallio, and
K Rhen
July 1973,
Medizinische Monatsschrift,
H Kallio, and
K Rhen
June 1989,
Drug and therapeutics bulletin,
H Kallio, and
K Rhen
April 1978,
Fortschritte der Medizin,
H Kallio, and
K Rhen
March 1974,
The Journal of reproductive medicine,
