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Overeating and obesity relative to controls was produced by multiple bilateral injections of 0.5 mg of amphetamine in the lateral ventricles of female rats eating a palatable, high fat diet. This behavioral and physiological rebound following the expected period of anorexia was accompanied by long-term depletion of dopamine in the striatum and of norepinephrine in the hypothalamus. This suggested the next experiment in which 50 micrograms of amphetamine were injected repeatedly in the lateral hypothalamus; again a brief period of anorexia was followed by hyperphagia and chronic obesity. This suggests that amphetamine acts in the lateral hypothalamus not only to suppress feeding, but in high doses it may also have local neurotoxic effects that cause an upward shift in body weight maintained by overeating.
L Hernandez, and
M Parada, and
B G Hoebel
January 1973,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
L Hernandez, and
M Parada, and
B G Hoebel
December 1967,
Transactions of the New York Academy of Sciences,
L Hernandez, and
M Parada, and
B G Hoebel
September 1975,
Science (New York, N.Y.),
L Hernandez, and
M Parada, and
B G Hoebel
November 1980,
The American journal of physiology,
L Hernandez, and
M Parada, and
B G Hoebel
September 1981,
Physiology & behavior,
L Hernandez, and
M Parada, and
B G Hoebel
August 1969,
Journal of comparative and physiological psychology,
L Hernandez, and
M Parada, and
B G Hoebel
March 1957,
Experientia,
L Hernandez, and
M Parada, and
B G Hoebel
November 1973,
Science (New York, N.Y.),
L Hernandez, and
M Parada, and
B G Hoebel
January 1977,
Science (New York, N.Y.),
L Hernandez, and
M Parada, and
B G Hoebel
April 1976,
Science (New York, N.Y.),
