Biomaterial Database

Haemolysis of human erythrocytes by the Fusobacterium nucleatum associated with periodontal disease. 1983

W A Falkler, and E B Clayman, and D F Shaefer

Fusobacterium nucleatum and Bacteroides gingivalis are associated with oral disease. They both attach to haemagglutinate and human erythrocytes. Experiments were performed to determine whether haemolysis would occur following attachment of strains of F. nucleatum and Bacteroides species including B. gingivalis. The F. nucleatum strains consistently displayed both haemagglutination and haemolytic activity. The B. gingivalis strains and other Bacteroides species displayed haemagglutination but no measurable haemolytic activity. Varying the concentration of the F. nucleatum whole cells in the standard haemolysis assay suggested a F. nucleatum-erythrocyte binding site interaction. The haemolytic moiety was observed in various cell, cell wall and lipopolysaccharide extracts.

UI	MeSH Term	Description	Entries
D002241	Carbohydrates	A class of organic compounds composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n. The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES.	Carbohydrate
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005673	Fusobacterium	A genus of gram-negative, anaerobic, rod-shaped bacteria found in cavities of humans and other animals. No endospores are formed. Some species are pathogenic and occur in various purulent or gangrenous infections.	Sphaerophorus
D006384	Hemagglutination	The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).	Hemagglutinations
D006461	Hemolysis	The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	Haemolysis,Extravascular Hemolysis,Intravascular Hemolysis,Extravascular Hemolyses,Haemolyses,Hemolyses, Extravascular,Hemolyses, Intravascular,Hemolysis, Extravascular,Hemolysis, Intravascular,Intravascular Hemolyses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001439	Bacteroides	A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.