Biomaterial Database

Phenytoin-induced gingival overgrowth resulting in delayed eruption of the primary dentition. A case report. 1984

L F Church, and S K Brandt

A case of delayed eruption of the primary dentition secondary to phenytoin therapy in a 4-year-old child is reported. The patient had been on phenytoin therapy since the first months of life. Radiographs revealed that alveolar but not gingival emergence had occurred. Surgical excision of the excess gingival tissue was accomplished under general anesthesia. Oral hygiene procedures were stressed and parental cooperation solicited. Three- and nine-month postoperative visits revealed no regrowth of gingival tissue and continued eruption of the primary dentition.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010672	Phenytoin	An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.	Diphenylhydantoin,Fenitoin,Phenhydan,5,5-Diphenylhydantoin,5,5-diphenylimidazolidine-2,4-dione,Antisacer,Difenin,Dihydan,Dilantin,Epamin,Epanutin,Hydantol,Phenytoin Sodium,Sodium Diphenylhydantoinate,Diphenylhydantoinate, Sodium
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D005885	Gingival Hyperplasia	Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski's Dictionary of Dentistry, 1992, p400)	Gingival Hyperplasias,Hyperplasia, Gingival,Hyperplasias, Gingival
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014078	Tooth Eruption	The emergence of a tooth from within its follicle in the ALVEOLAR PROCESS of the MAXILLA or MANDIBLE into the ORAL CAVITY. (Boucher's Clinical Dental Terminology, 4th ed)	Teething,Eruption, Tooth,Eruptions, Tooth,Tooth Eruptions
D014094	Tooth, Deciduous	The teeth of the first dentition, which are shed and replaced by the permanent teeth.	Primary Tooth,Tooth, Primary,Baby Teeth,Baby Tooth,Dentition, Deciduous,Dentition, Primary,Milk Teeth,Milk Tooth,Primary Teeth,Teeth, Deciduous,Teeth, Primary,Deciduous Dentition,Deciduous Dentitions,Deciduous Teeth,Deciduous Tooth,Dentitions, Deciduous,Dentitions, Primary,Primary Dentition,Primary Dentitions,Teeth, Baby,Teeth, Milk,Tooth, Baby,Tooth, Milk