-transparent.png){kind=logo}
A series of mouse-hamster somatic cell hybrids, containing reduced numbers of mouse chromosomes and a complete set of hamster chromosomes, was used to determine the chromosomal locations of the genes for the alpha and beta subunits of mouse thyrotropin. Cloned cDNA probes for each subunit, in conjunction with Southern blot analysis of DNA treated with the restriction enzyme BamHI, allowed for assignment of the alpha-subunit gene to mouse chromosome 4 and of the beta-subunit gene to chromosome 3. Mouse alpha-subunit gene sequences always segregated with chromosome 4 (concordant in 14 hybrids) and the enzyme markers phosphoglucomutase 2 and 6-phosphogluconate dehydrogenase. Mouse beta-subunit gene sequences always segregated with chromosome 3 (concordant in 15 hybrids). Thus, the genes for at least one of the glycoprotein hormones, thyrotropin, are on different chromosomes.
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
November 1977,
Comprehensive therapy,
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
August 1987,
Proceedings of the National Academy of Sciences of the United States of America,
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
November 1983,
Somatic cell genetics,
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
January 1992,
Cytogenetics and cell genetics,
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
November 1987,
Human genetics,
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
February 1978,
Proceedings of the National Academy of Sciences of the United States of America,
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
January 1989,
Progress in clinical and biological research,
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
July 1989,
Genomics,
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
August 1997,
Human genetics,
I A Kourides, and
P E Barker, and
J A Gurr, and
D D Pravtcheva, and
F H Ruddle
May 1986,
The Biochemical journal,
