Biomaterial Database

Trihalomethanes in drinking water and human colorectal cancer. 1984

C E Lawrence, and P R Taylor, and B J Trock, and A A Reilly

The relation of trihalomethanes (THM) to colorectal cancer was evaluated. A total of 395 colorectal cancer deaths among white women teachers in New York State was compared to an equal number of deaths of teachers from noncancerous causes. Cumulative chloroform (CHCl3) exposure was estimated by the application of a statistical model to operational records from the individual water treatment facilities that served the home and work addresses of each study subject during the 20 years prior to death. The odds of exposure to a surface source containing little or no THM was no greater for cases than for controls. The odds ratio = 1.07; the 90% confidence interval = 0.79-1.43; and the P = .68. The distribution of CHCl3 exposure was not significantly different between cases and controls (rated by Wilcoxon signed rank statistic = -0.52; P = .60). No effect of cumulative CHCl3 exposure on outcome was seen in a logistic analysis controlling for average source type, population density, marital status, age, and year of death (likelihood ratio test statistic = 0.047; P = .83).

UI	MeSH Term	Description	Entries
D009518	New York	State bounded on the north by Lake Ontario and Canada, on the east by Vermont, Massachusetts, and Connecticut, on the south by the Atlantic Ocean, New Jersey, and Pennsylvania, and on the west by Pennsylvania, Lake Erie, and Canada.
D012004	Rectal Neoplasms	Tumors or cancer of the RECTUM.	Cancer of Rectum,Rectal Cancer,Rectal Tumors,Cancer of the Rectum,Neoplasms, Rectal,Rectum Cancer,Rectum Neoplasms,Cancer, Rectal,Cancer, Rectum,Neoplasm, Rectal,Neoplasm, Rectum,Rectal Cancers,Rectal Neoplasm,Rectal Tumor,Rectum Cancers,Rectum Neoplasm,Tumor, Rectal
D002725	Chloroform	A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.	Trichloromethane
D003110	Colonic Neoplasms	Tumors or cancer of the COLON.	Cancer of Colon,Colon Adenocarcinoma,Colon Cancer,Cancer of the Colon,Colon Neoplasms,Colonic Cancer,Neoplasms, Colonic,Adenocarcinoma, Colon,Adenocarcinomas, Colon,Cancer, Colon,Cancer, Colonic,Cancers, Colon,Cancers, Colonic,Colon Adenocarcinomas,Colon Cancers,Colon Neoplasm,Colonic Cancers,Colonic Neoplasm,Neoplasm, Colon,Neoplasm, Colonic,Neoplasms, Colon
D005178	Faculty	TEACHING and administrative staff having academic rank in a post-secondary educational institution.	University Professor,Professor, University,Professors, University,University Professors
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D012574	Schools	Educational institutions.	Primary Schools,Schools, Secondary,Secondary Schools,Primary School,School,School, Primary,School, Secondary,Schools, Primary,Secondary School
D013223	Statistics as Topic	Works about the science and art of collecting, summarizing, and analyzing data that are subject to random variation.	Area Analysis,Estimation Technics,Estimation Techniques,Indirect Estimation Technics,Indirect Estimation Techniques,Multiple Classification Analysis,Service Statistics,Statistical Study,Statistics, Service,Tables and Charts as Topic,Analyses, Area,Analyses, Multiple Classification,Area Analyses,Classification Analyses, Multiple,Classification Analysis, Multiple,Estimation Technic, Indirect,Estimation Technics, Indirect,Estimation Technique,Estimation Technique, Indirect,Estimation Techniques, Indirect,Indirect Estimation Technic,Indirect Estimation Technique,Multiple Classification Analyses,Statistical Studies,Studies, Statistical,Study, Statistical,Technic, Indirect Estimation,Technics, Estimation,Technics, Indirect Estimation,Technique, Estimation,Technique, Indirect Estimation,Techniques, Estimation,Techniques, Indirect Estimation
D014881	Water Supply	Means or process of supplying water (as for a community) usually including reservoirs, tunnels, and pipelines and often the watershed from which the water is ultimately drawn. (Webster, 3d ed)	Supplies, Water,Supply, Water,Water Supplies