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A model of obturation hematogenous pyelonephritis was reproduced in rats by infecting them with Pseudomonas aeruginosa. On the model subject to study was chemotherapeutic activity of dioxidine (50--100 mg/kg per day) as compared to gentamycin (5 mg/kg per day). The drugs were administered intramuscularly for 7 days, starting 24 hours after inoculation of the animals. The action of both dioxidine and gentamycin on lethality, bacteriura, the mass of the kidneys and macroscopic changes in them was approximately the same, but dioxidine extered a greater influence on the seeding rate of the causative agent coming from the kidneys. Both drugs fail to bring about complete recovery of the animals.
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
January 1982,
Farmakologiia i toksikologiia,
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
March 1976,
The Indian journal of medical research,
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
November 1964,
Laboratory investigation; a journal of technical methods and pathology,
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
May 1973,
Acta pathologica et microbiologica Scandinavica. Section A, Pathology,
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
August 1951,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
January 1985,
TSitologiia i genetika,
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
April 1972,
Zeitschrift fur Urologie und Nephrologie,
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
October 1974,
Antimicrobial agents and chemotherapy,
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
February 1964,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E A Rudzit, and
L I Lisitsa, and
T A Zinchenko
December 1981,
Clinical nephrology,
