-transparent.png){kind=logo}
The cytotoxic effect of prostaglandin (PG) D2, PGE1 and PGF2 alpha was examined on human osteosarcoma cells (KSu cell line) in vitro, and PGD2 was most effective. DNA, RNA and protein syntheses of KSu cells were also found to be inhibited by PGD2 at a concentration of 5 micrograms/ml. Furthermore, the proliferation of various human malignant tumor cells was inhibited by PGD2 without exception so far. These results suggest that PGD2 shows an anti-neoplastic effect on a variety of human malignant tumor cells.
Related Publications
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
November 2021,
Anti-cancer drugs,
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
September 1974,
Thrombosis research,
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
September 1983,
Prostaglandins, leukotrienes, and medicine,
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
January 2018,
Endocrine,
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
November 1979,
Nature,
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
April 2002,
The European respiratory journal,
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
May 2010,
Molecular and cellular endocrinology,
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
January 2014,
Oncoscience,
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
June 2020,
Allergy,
T Sakai, and
N Yamaguchi, and
Y Shiroko, and
M Sekiguchi, and
G Fujii, and
H Nishino
March 1989,
Biochemical and biophysical research communications,
