-transparent.png){kind=logo}
A culture of dispersed rat anterior pituitary cells was used to test the ability of pimozide and sulpiride to affect the basal gonadotropin release and their effects on the response to Gn-RH. Sulpiride did not alter either the basal or the Gn-RH-induced release of LH, and the lowest dose (500 ng/ml) seemed to potentiate the Gn-RH-induced FSH release. On the other hand, both doses of pimozide (100 ng/ml and 10 microgram/ml) significantly inhibited the release of FSH and LH induced by Gn-RH but did not affect the basal release of the two gonadotropins. From these results it is evident that pimozide, at the doses used, is a powerful inhibitor of the pituitary response to Gn-RH in vitro. Sulpiride on the other hand had no effect on the pituitary response to Gn-RH in vitro, except on FSH release, using the lower dose.
L Debeljuk, and
A Khar, and
M Jutisz
June 1976,
Endocrinology,
L Debeljuk, and
A Khar, and
M Jutisz
January 1993,
Reproduction, nutrition, development,
L Debeljuk, and
A Khar, and
M Jutisz
August 1978,
Clinics in obstetrics and gynaecology,
L Debeljuk, and
A Khar, and
M Jutisz
October 1988,
Neuroendocrinology,
L Debeljuk, and
A Khar, and
M Jutisz
January 2011,
Neuro endocrinology letters,
L Debeljuk, and
A Khar, and
M Jutisz
December 1981,
Endocrinologia experimentalis,
L Debeljuk, and
A Khar, and
M Jutisz
January 1973,
Metabolism: clinical and experimental,
L Debeljuk, and
A Khar, and
M Jutisz
November 1984,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
L Debeljuk, and
A Khar, and
M Jutisz
August 1986,
Molecular and cellular endocrinology,
L Debeljuk, and
A Khar, and
M Jutisz
August 1977,
Acta endocrinologica,
