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The pattern of lactate dehydrogenase isozymes was investigated by means of electrophoresis in erythrocytes of CBA/Lac and DBA/2J mice homozygous for b and a alleles of the Ldr-1 locus. It is found that differences in the pattern of LDH isozymes, homozygous for the genes Ldr-1a and Ldr-1b, consist in increased activity of the isozyme LDH-4 in mice homozygous for the gene Ldr-1a (DBA/2J) within 12-14 days of postnatal development. Inhibition of the reaction between 125I-LDH-1 and the respective antibodies has demonstrated that increased LDH-4 activity during development is related to the higher content of B-subunits of LDH. It is suggested that the mechanism of the action of the gene Ldr-1 involves changes in the rate of the synthesis and degradation of B-subunit of LDH.
T M Khlebodarova, and
O L Serov, and
L I Korochkin
May 1969,
The British journal of dermatology,
T M Khlebodarova, and
O L Serov, and
L I Korochkin
December 1975,
Biulleten' eksperimental'noi biologii i meditsiny,
T M Khlebodarova, and
O L Serov, and
L I Korochkin
April 1973,
Vrachebnoe delo,
T M Khlebodarova, and
O L Serov, and
L I Korochkin
July 1970,
Biulleten' eksperimental'noi biologii i meditsiny,
T M Khlebodarova, and
O L Serov, and
L I Korochkin
January 1978,
Voprosy onkologii,
T M Khlebodarova, and
O L Serov, and
L I Korochkin
September 1974,
Vestnik dermatologii i venerologii,
T M Khlebodarova, and
O L Serov, and
L I Korochkin
January 1981,
Voprosy meditsinskoi khimii,
T M Khlebodarova, and
O L Serov, and
L I Korochkin
January 1972,
Zhurnal evoliutsionnoi biokhimii i fiziologii,
T M Khlebodarova, and
O L Serov, and
L I Korochkin
November 1972,
Kardiologiia,
T M Khlebodarova, and
O L Serov, and
L I Korochkin
February 1985,
Tsitologiia,
