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A technique for determination of the prostaglandin E2 biosynthetic capacity ( PGBC ) of gastric mucosa is described. The effects of food deprivation and indomethacin pretreatment on PGBC were studied. Indomethacin (1 mg/kg i.p.) significantly reduced the PGBC of fundal and antral tissue. This effect was more marked in the fundal tissue. Food deprivation for up to 22 h had no effect on fundal PGBC . In the antrum, a 12-hour fast caused a significant reduction in PGBC while a 22-hour fast had no effect. These changes in PGBC may relate to the increase in susceptibility to gastric ulceration caused by fasting or indomethacin pretreatment. This technique may be applicable to clinical studies.
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
September 1984,
Arkhiv anatomii, gistologii i embriologii,
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
November 1993,
Biochemical pharmacology,
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
January 1954,
Acta medica Academiae Scientiarum Hungaricae,
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
October 1982,
The Journal of biological chemistry,
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
December 1979,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
September 1996,
Gut,
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
September 1981,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
August 1969,
Naika hokan. Japanese archives of internal medicine,
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
May 1985,
The Biochemical journal,
J L Wallace, and
D R McCready, and
B C Chin, and
N S Track, and
M M Cohen
January 1983,
Comparative biochemistry and physiology. B, Comparative biochemistry,
