A wide variety of diseases of the soft tissues of the oral cavity occur. Some of the common and significant problems have been presented with recommendations for their management. Diagnosis and patient evaluation including adequate laboratory studies when required, are the keys to a more successful outcome of treatment. Antibiotics and short-term anti-inflammatory steroids benefit selected cases. In others, treatment may require a team approach in concert with the physician. Dentists should be alert to causes of the oral lesions, especially in cases of xerostomia, candidiasis, and nutritional deficiencies. This article should form a basis for therapy of stomatologic problems.