-transparent.png){kind=logo}
The ECG effect of amsacrine (m-AMSA) was evaluated in 12 consecutive patients with leukemia. m-AMSA induced a significant prolongation of the Q-T interval (msecs, mean +/- SE) before (448 +/- 13) and 1 hour after (512 +/- 12) treatment (P . 0.0001, paired t test), without concomitant changes in the P-R interval, QRS duration, and heart rate. This selective cardiotoxic effect appeared to be transient and was noted towards the end of the iv drug administration, but was not present 24 hours later. No cardiac arrhythmias were noted during continuous monitoring. Nevertheless, it is assumed that the prolongation of the Q-T interval may represent a state of increased vulnerability to rhythm disturbances. Special care should be taken to avoid factors that may prolong the Q-T interval (hypokalemia, ischemia, or premedication with phenothiazine) during the administration of m-AMSA.
E Shinar, and
Y Hasin
January 1959,
Acta medica Academiae Scientiarum Hungaricae,
E Shinar, and
Y Hasin
January 1983,
Archives of internal medicine,
E Shinar, and
Y Hasin
January 1972,
Atti della Accademia medica lombarda,
E Shinar, and
Y Hasin
January 1964,
Gazeta medica portuguesa,
E Shinar, and
Y Hasin
January 1983,
Cancer chemotherapy and pharmacology,
E Shinar, and
Y Hasin
October 1965,
American heart journal,
E Shinar, and
Y Hasin
May 1975,
La Nouvelle presse medicale,
E Shinar, and
Y Hasin
January 1975,
Bollettino della Societa italiana di cardiologia,
E Shinar, and
Y Hasin
March 1965,
Revista medica de Chile,
E Shinar, and
Y Hasin
January 1962,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
