Treatment of vaginal endometriosis with danazol. 1984

A I Koskimies, and B Meyer, and O Widholm

Six infertile patients with vaginal endometriosis were treated with danazol at 600 mg daily for 6 months. Three patients had previously undergone surgery for pelvic endometriosis. After 4 months of danazol treatment there was a clear reduction in the size and number of the lesions in all the patients. At the end of the treatment 4 patients still had small lesions, which showed histological evidence of regressive changes. Four women became pregnant within 6 months of the termination of therapy.

UI MeSH Term Description Entries
D007246 Infertility A reduced or absent capacity to reproduce. Sterility,Reproductive Sterility,Sterility, Reproductive,Sub-Fertility,Subfertility
D008297 Male Males
D011245 Pregnadienes Pregnane derivatives containing two double bonds anywhere within the ring structures.
D003613 Danazol A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. Azol,Cyclomen,Danatrol,Danazant,Danazol-Ratiopharm,Danocrine,Danol,Danoval,Ladogal,Norciden,Panacrine,Danazol Ratiopharm
D004715 Endometriosis A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum. Endometrioma,Endometriomas,Endometrioses
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014623 Vaginal Diseases Pathological processes of the VAGINA. Disease, Vaginal,Diseases, Vaginal,Vaginal Disease

Related Publications

A I Koskimies, and B Meyer, and O Widholm
February 1976, The Journal of the Maine Medical Association,
A I Koskimies, and B Meyer, and O Widholm
January 1975, American journal of obstetrics and gynecology,
A I Koskimies, and B Meyer, and O Widholm
August 1985, Fertility and sterility,
A I Koskimies, and B Meyer, and O Widholm
December 2011, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
A I Koskimies, and B Meyer, and O Widholm
October 2007, Fertility and sterility,
A I Koskimies, and B Meyer, and O Widholm
March 1987, Obstetrics and gynecology,
A I Koskimies, and B Meyer, and O Widholm
January 1981, Acta obstetricia et gynecologica Scandinavica,
A I Koskimies, and B Meyer, and O Widholm
November 1980, Minerva ginecologica,
A I Koskimies, and B Meyer, and O Widholm
April 1973, The Journal of reproductive medicine,
A I Koskimies, and B Meyer, and O Widholm
May 1989, The British journal of clinical practice,
Copied contents to your clipboard!