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To evaluate the effects of parenteral imipenem/cilastatin therapy upon human faecal microflora, stool specimens obtained from ten patients before, during and after therapy were cultured quantitatively for aerobic and anaerobic microorganisms. The patients received 500 mg imipenem combined with 500 mg cilastatin every 6 h for 6-11 days. The antimicrobial therapy was associated with a small decrease in the numbers of enterobacteria, anaerobic cocci and bacteroides during treatment but afterward the microflora normalized in all patients. None of the patients was colonized with new imipenem-resistant bacteria, had Clostridium difficile or cytotoxin in the stools, or developed diarrhoea.
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
June 1985,
The American journal of medicine,
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
May 1986,
Antimicrobial agents and chemotherapy,
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
December 1986,
The Journal of antimicrobial chemotherapy,
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
June 1985,
The American journal of medicine,
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
October 1992,
Transplantation proceedings,
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
October 1984,
European journal of clinical microbiology,
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
August 1988,
Lancet (London, England),
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
September 1992,
Obstetrics and gynecology clinics of North America,
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
January 1985,
Reviews of infectious diseases,
C E Nord, and
L Kager, and
A Philipson, and
G Stiernstedt
March 1989,
Critical care nurse,
