-transparent.png){kind=logo}
Fifteen adult patients with refractory or relapsing acute lymphoblastic leukemia (ALL) received a 5-day remission induction regimen consisting of VP 16-213 (60 mg/m2 every 12 hr) and cytosine-arabinoside (100 mg/m2 every 12 hr) up to a maximum of three courses. The overall response rate was 60% (9/15), four patients (27%) achieving CR and five (33%) attaining PR. Responders were maintained with monthly courses of the same combination until progressive disease developed. The median duration of response was 4.5 months (2-12+ months). The regimen was relatively well tolerated. The major toxicity was hematologic. Non-hematologic toxicities included mild nausea and vomiting (11/15) and total alopecia (15/15). The results obtained with this combination are encouraging, in view of the poor prognosis associated with refractory or relapsing ALL in adults.
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
April 1986,
Gan to kagaku ryoho. Cancer & chemotherapy,
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
September 1984,
Cancer,
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
July 1986,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
January 1990,
Haematology and blood transfusion,
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
September 1984,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
August 1982,
European journal of cancer & clinical oncology,
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
January 1989,
Hematological oncology,
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
January 1991,
Haematologica,
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
January 1984,
Sangre,
E Morra, and
M Lazzarino, and
E P Alessandrino, and
D Inverardi, and
A Canevari, and
C Bernasconi
June 1987,
Seminars in oncology,
