-transparent.png){kind=logo}
1 alpha,25-Dihydroxyvitamin D3 [1 alpha,25-(OH)2D3] induces fusion of murine alveolar macrophages. This effect was observed in growth medium containing 5% human serum but not in the medium with 5% fetal bovine serum. Unlike 1 alpha,25-(OH)2D3, bacterial lipopolysaccharides (LPS) did not induce fusion of alveolar macrophages. However, both 1 alpha,25-(OH)2D3 and LPS activated alveolar macrophages, as measured by glucose consumption, increase in Fc receptors, and induction of cytotoxicity. The number of Fc receptors on the surface of multinucleated giant cells induced by 1 alpha,25-(OH)2D3 was much smaller than that on the surface of mononuclear macrophages treated with the hormone. These results indicate that 1 alpha,25-(OH)2D3 induces both fusion and activation of alveolar macrophages, whereas LPS elicits activation only.
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
August 1986,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
October 1988,
Journal of cellular physiology,
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
January 1991,
Experimental cell research,
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
April 1986,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
February 1990,
Journal of cellular physiology,
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
May 1987,
Endocrinology,
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
January 1989,
Experimental cell research,
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
December 1987,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
March 1995,
The Journal of biological chemistry,
E Abe, and
Y Shiina, and
C Miyaura, and
H Tanaka, and
T Hayashi, and
S Kanegasaki, and
M Saito, and
Y Nishii, and
H F DeLuca, and
T Suda
May 1990,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
