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A method is given for the determination of daunorubicin and its main metabolite, daunorubicinol, in plasma from leukemic patients after administration of daunorubicin as the free drug or as a complex with DNA. Daunorubicin and daunorubicinol are extracted from 2 ml of plasma (pH 8.1) using a mixture of chloroform and 1-heptanol (9:1). After re-extraction into phosphoric acid (0.1 M), the separation is performed as reversed phase liquid chromatography on a LiChrosorb RP-2 (5 micrometer) column with a mobile phase of acetonitrile-water, acidified with phosphoric acid. The precision, by quantitation with a photometric detector, was better than 2% within the range 20 ng/ml to 200 ng/ml. Some determinations of plasma levels of daunorubicin and daunorubicinol are presented.
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
April 1977,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
December 2002,
Journal of chromatography. A,
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
January 1980,
Cancer chemotherapy and pharmacology,
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
July 2001,
Journal of chromatography. B, Biomedical sciences and applications,
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
January 1995,
Cancer chemotherapy and pharmacology,
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
May 1977,
The Journal of antibiotics,
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
June 1983,
Clinical chemistry,
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
June 1983,
Clinical chemistry,
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
February 1978,
Journal of chromatography,
S Eksborg, and
H Ehrsson, and
B Andersson, and
M Beran
February 1981,
Journal of chromatography,
