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The immune response against six synthetic peptides corresponding to various segments of the B subunit of cholera toxin was evaluated. Conjugates in which the peptides were covalently linked to tetanus toxoid served for immunization of rabbits. As previously reported, four of these conjugates elicited antibodies cross-reactive with intact cholera toxin. We report here that antisera against two of these synthetic peptides inhibit the entire spectrum of activities of the intact cholera toxin. This is manifested both on the biochemical level (adenylate cyclase induction) and on the biological effect (intestinal fluid secretion). These results indicate that these peptides may serve as suitable candidates for preparation of a synthetic anticholera vaccine.
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
January 1979,
Progress in clinical and biological research,
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
September 1975,
Proceedings of the National Academy of Sciences of the United States of America,
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
December 1989,
Biochimica et biophysica acta,
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
September 1976,
The Biochemical journal,
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
February 1976,
The Journal of clinical investigation,
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
July 1975,
FEBS letters,
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
December 1976,
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften,
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
February 1985,
European journal of biochemistry,
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
July 1991,
The Journal of biological chemistry,
C O Jacob, and
M Sela, and
M Pines, and
S Hurwitz, and
R Arnon
January 1979,
Journal of supramolecular structure,
