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The effects of erythromycin estolate, a well known hepatotoxic macrolide antibiotic, on isolated rat hepatocyte viability and on subcellular Ca2+ transport have been investigated. Erythromycin estolate (0.5 mM), but not erythromycin base and erythromycin ethylsuccinate, induced 100% cell death after 60 min incubation, and caused maximal inhibition of mitochondrial and microsomal Ca2+ sequestration activities at 0.1 mM concentration. Sodium lauryl sulphate, which is the surfactant moiety of the erythromycin estolate molecule, caused effects similar to those exhibited by erythromycin estolate. Disorders of the intracellular calcium homeostasis seem to play a role in the lauryl sulphate-mediated hepatotoxic action of erythromycin estolate.
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
March 1978,
American journal of diseases of children (1960),
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
December 1992,
Atencion primaria,
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
August 1982,
Digestive diseases and sciences,
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
November 1977,
Antimicrobial agents and chemotherapy,
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
May 2004,
Pharmacological research,
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
January 2003,
Therapie,
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
July 1988,
Lancet (London, England),
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
June 1983,
British medical journal (Clinical research ed.),
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
June 1963,
Canadian Medical Association journal,
P Richelmi, and
C Baldi, and
L Manzo, and
F Berte, and
A P Martino, and
F Mirabelli, and
G Bellomo
September 1974,
Ugeskrift for laeger,
