BIOMAT Database Logo BIOMAT Database Logo

Distribution and metabolism of 2-t-butyl-4-methoxyphenol in the everted rat gut preparation. 1984

L Della Corte, and M G Giovannini, and G P Sgaragli

The distribution of BHA and its conversion to di-BHA in the everted rat gut preparation was monitored by GC/MS analysis of both compounds in the mucosal and serosal side solutions and in the ileum wall. Following 1 h incubation at 27 degrees C, BHA concentration in the mucosal side solution was found to decay from an initial value of 0.1 mM down to 0.033 mM, while in the ileum it reached a 0.35 mM concentration. The amount of di-BHA found at this time in the ileum wall accounted for the transformation of 5% of the amount of BHA present in this compartment.

UI MeSH Term Description Entries
D007082 Ileum The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D007413 Intestinal Mucosa Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI. Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D008297 Male Males
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002083 Butylated Hydroxyanisole Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals. Butylhydroxyanisole,(1,1-Dimethylethyl)-4-methoxyphenol,AMIF-72,BHA,Butyl Methoxyphenol,Embanox,Nipantiox 1-F,Tenox BHA,AMIF 72,AMIF72,Hydroxyanisole, Butylated,Methoxyphenol, Butyl,Nipantiox 1 F,Nipantiox 1F
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000840 Anisoles A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O. Methylphenyl Ethers,Ethers, Methylphenyl
D001711 Biotransformation The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

L Della Corte, and M G Giovannini, and G P Sgaragli
Toxic injury to rat gut musculature following intraperitoneal administration of 2-t-butyl-4-methoxyphenol.
August 1993, European journal of pharmacology,
L Della Corte, and M G Giovannini, and G P Sgaragli
Distribution and peroxidative oxidation of 2-t-butyl-4-methoxyphenol in rat tissues after a single intraperitoneal dose.
January 1989, Journal of biochemical toxicology,
L Della Corte, and M G Giovannini, and G P Sgaragli
Purification and characterization of rat intestinal peroxidase. Its activity towards 2-t-butyl-4-methoxyphenol (BHA).
March 1988, The Biochemical journal,
L Della Corte, and M G Giovannini, and G P Sgaragli
Oxidation of 2-t-butyl-4-methoxyphenol (BHA) by horseradish and mammalian peroxidase systems.
March 1980, Biochemical pharmacology,
L Della Corte, and M G Giovannini, and G P Sgaragli
Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus.
October 1998, European journal of pharmacology,
L Della Corte, and M G Giovannini, and G P Sgaragli
Free radical intermediates during peroxidase oxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds.
March 1989, Archives of biochemistry and biophysics,
L Della Corte, and M G Giovannini, and G P Sgaragli
2-t-Butyl-4-methoxyphenol (BHA) acute toxicity in rodents: influence of the administration route.
October 1984, Pharmacological research communications,
L Della Corte, and M G Giovannini, and G P Sgaragli
THE PREPARATION OF N-T-BUTYL-4-PIPERIDONE.
March 1965, Journal of the Chemical Society,
L Della Corte, and M G Giovannini, and G P Sgaragli
Complexation of uranium by 2-(2-thiazolylazo)-4-methoxyphenol and 2-(2-thiazolylazo)-5-methoxyphenol.
September 1968, Talanta,
L Della Corte, and M G Giovannini, and G P Sgaragli
2-(2-thiazolylazo)-4-methoxyphenol and 2-(2-thiazolylazo)-5-methoxyphenol as metal-ion indicators.
March 1967, Talanta,
Copied contents to your clipboard!