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The rate of calcium transport in the erythrocytes in both forms of primary hypertension [essential hypertension (EH) of humans and spontaneously hypertensive rats (SHR)] and in microsomes of SHR brain were studied. In the erythrocyte membranes subjected to calmodulin depletion by EGTA treatment both the affinity of the Ca-pump for Ca2+ and its maximal activity in primary hypertension did not differ from normotensive controls. The addition of exogenous calmodulin to calmodulin-stripped membranes from erythrocytes of EH or SHR and microsomes of SHR brain resulted in a smaller increase of the Ca-pump activity. It is suggested that the decrease of the rate of calmodulin-dependent calcium transport across the plasma membrane may be a cause for the increased intracellular calcium content found in some tissues in primary hypertension.
Y V Postnov, and
S N Orlov
October 1980,
The Journal of biological chemistry,
Y V Postnov, and
S N Orlov
May 1990,
Biokhimiia (Moscow, Russia),
Y V Postnov, and
S N Orlov
July 1983,
Journal of neurochemistry,
Y V Postnov, and
S N Orlov
January 1989,
Ukrainskii biokhimicheskii zhurnal (1978),
Y V Postnov, and
S N Orlov
November 1975,
FEBS letters,
Y V Postnov, and
S N Orlov
June 1981,
Archives of biochemistry and biophysics,
Y V Postnov, and
S N Orlov
December 1980,
Nature,
Y V Postnov, and
S N Orlov
September 1982,
Molecular pharmacology,
Y V Postnov, and
S N Orlov
June 1981,
Biochimica et biophysica acta,
Y V Postnov, and
S N Orlov
September 1997,
Molecular reproduction and development,
