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Male Syrian hamsters were scheduled to be exposed by inhalation approximately every 60 days for 1 year (7 exposures) to aerosols of 239PuO2 beginning at 84 days of age. Other hamsters were exposed once when 84 or 320 days of age. Plutonium-239 deposited in the lungs by the repeated inhalation exposures was cleared from the lungs at a rate similar to that following a single inhalation exposure. The incidence of radiation pneumonitis, bronchiolar epithelial hyperplasia, and alveolar squamous metaplasia were the only lesions that were related to radiation dose. Only two primary lung tumours were found among the hamsters exposed to 239PuO2. No primary lung tumours were found in the control hamsters. It was concluded that the incidence of lung tumours was not increased by the protraction of the alpha radiation dose to the lungs from repeated inhalation exposure.
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
December 1981,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
May 1977,
Radiation research,
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
November 1982,
Health physics,
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
September 1975,
Archives of environmental health,
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
December 1979,
Toxicology,
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
May 1979,
The Review of scientific instruments,
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
June 1979,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Betriebshygiene, praventive Medizin,
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
December 1976,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin,
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
April 1978,
Radiation research,
D L Lundgren, and
F F Hahn, and
A H Rebar, and
R O McClellan
October 1981,
Health physics,
