The authors carried out computer-tomographic examinations of the head of 115 patients suffering from disseminated sclerosis. Various pathological signs, such as a distention of the cerebral ventricles and the subarachnoidal space, a diminution of the cerebellum volume, and presence of lowered-density foci, were revealed in 72% of the patients. 34 lowered-density foci appeared to be subclinical. The computer-tomographic findings were correlated with the disease phase and duration, and the results of the correlation were analyzed. In the phase of the process exacerbation, the lowered-density foci were found more frequently than in the phase of remission, the frequency increase being statistically significant. The distention of the brain ventricles and subarachnoidal space was observed twice as more frequently in patients with a disease duration of over 5 years, than in patients who were ill for 5 years or less. In 3 patients with the spinal form of the disease, a number of signs of brain affection were revealed on the computer-tomographic examination. The data obtained are discussed.