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In 144 patients, creatine kinase MB was measured serially at 0, 8, 16, 24, 48, and 72 hr using a two-site immunoradiometric assay (IRMA). Cardiac enzymes were also measured, including SGOT, LDH, total CPK, and CK-MB by electrophoresis. The presence of perioperative myocardial infarction (poMI) was established in 24 patients by the appearance of new electrocardiographic Q waves and/or new wall motion abnormalities detected by radionuclide ventriculography. In patients without poMI, CK-MB (IRMA) was elevated (6.4 +/- 4.9 equivalent units per liter) at 0-8 hr but decreased to 3.4 +/- 1.3 EU/l by 16 hr. In patients with poMI, peak values occurred at 16-24 hr (21.0 +/- 19.8 EU/l). Using a threshold value of 8.5 EU/l, patients with poMI could be distinguished from those without with 97% accuracy (sensitivity = 88%, specificity = 99%). The CK-MB (IRMA) was more reliable than the other enzyme assays, for which we used both empirically elevated threshold values based upon previous experience, and also threshold values retrospectively optimized for the study population. We conclude that the CK-MB (IRMA) can serve as a valuable postoperative screening test for poMI.
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
June 1981,
Clinica chimica acta; international journal of clinical chemistry,
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
March 1984,
Clinical chemistry,
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
October 1980,
Biochemical Society transactions,
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
October 1993,
Military medicine,
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
September 1977,
Lancet (London, England),
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
February 1978,
Clinica chimica acta; international journal of clinical chemistry,
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
August 1977,
Lancet (London, England),
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
December 1991,
New York state journal of medicine,
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
February 1986,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
E G DePuey, and
A Aessopos, and
L R Monroe, and
R J Hall, and
W L Thompson, and
R E Sonnemaker, and
J A Burdine
March 1979,
British medical journal,
