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The woman described suffered from a pruritic erythematous rash, edema, malaise and fever which appeared during Tegretol therapy. The patient was shown to have a severe hypogammaglobulinemia with absence of circulating B lymphocytes, but normal cell-mediated immunity. There was an absence of in vitro immunoglobulin production by the patient's cells, but this was not due to excessive T-suppressor activity or lack of T-cell help. When drug administration was stopped the edema and rash began to recede promptly, and a few months later her serum immunoglobulin levels, antibody titers and in vitro immunoglobulin production became normal. This transient, probably drug-dependent case of hypogammaglobulinemia, added to three previously reported cases, stresses the need of considering non-conventional immunosuppressive drugs as a potential-etiological agent in acquired hypogammaglobulinemia.
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
January 2022,
The Turkish journal of pediatrics,
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
February 1985,
Israel journal of medical sciences,
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
January 1973,
Pathologica,
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
March 1986,
Journal of clinical immunology,
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
January 1977,
Annales d'immunologie,
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
November 1981,
The New England journal of medicine,
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
November 2019,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
October 1989,
The Pediatric infectious disease journal,
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
July 1980,
Biulleten' eksperimental'noi biologii i meditsiny,
M C Garcia Rodriguez, and
E G de la Concha, and
G Fontán, and
D Pascual-Salcedo, and
J Fernandez, and
J A Ojeda, and
A Garcia Diaz
December 1984,
Medicina clinica,
