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Two monoclonal antibodies were obtained that showed unique specificities for the leukemic T cells used for immunization. One antibody, S160, was totally specific for the antigen. The other antibody, S511, also reacted with a small population of normal T cells. This was made especially evident by concentrating these normal T cells with the antibody. Considerable evidence was obtained that both antibodies reacted with the same membrane molecules. In the unreduced state a major component of approximately 80 kdaltons was observed; after reduction this split into two components of approximately 43 and approximately 38 kdaltons. The reaction of the two antibodies with different antigenic sites on the same molecule, one representing a private site and the other a more cross-reactive site, strongly suggests an antibodylike molecule, but composed of polypeptide chains differing from immunoglobulins.
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D E Fisher, and
C Y Wang, and
E A Rinnooy Kan, and
H G Kunkel
June 1977,
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R D Bigler, and
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C Y Wang, and
E A Rinnooy Kan, and
H G Kunkel
August 1988,
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R D Bigler, and
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E A Rinnooy Kan, and
H G Kunkel
February 2006,
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R D Bigler, and
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C Y Wang, and
E A Rinnooy Kan, and
H G Kunkel
June 1990,
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R D Bigler, and
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C Y Wang, and
E A Rinnooy Kan, and
H G Kunkel
December 1986,
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R D Bigler, and
D E Fisher, and
C Y Wang, and
E A Rinnooy Kan, and
H G Kunkel
July 1982,
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R D Bigler, and
D E Fisher, and
C Y Wang, and
E A Rinnooy Kan, and
H G Kunkel
August 1988,
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R D Bigler, and
D E Fisher, and
C Y Wang, and
E A Rinnooy Kan, and
H G Kunkel
April 1977,
Journal of immunology (Baltimore, Md. : 1950),
R D Bigler, and
D E Fisher, and
C Y Wang, and
E A Rinnooy Kan, and
H G Kunkel
July 1990,
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R D Bigler, and
D E Fisher, and
C Y Wang, and
E A Rinnooy Kan, and
H G Kunkel
August 1985,
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