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Cerebral tryptophan metabolism was studied in rat brain slices. The results show that serotonin production was inhibited at high levels of tryptophan or 5-oxo-L-prolyltryptophan. In contrast, kynurenine formation showed a dose dependent increase at the various concentrations of tryptophan or 5-oxo-L-prolyltryptophan. Measurements of the activities of tryptophan hydroxylase (TH) and indoleamine 2,3-dioxygenase (IDOase) in crude brain homogenates showed that serotonin formation was linear in the presence of dithiothreitol, whereas kynurenine production was inhibited in the presence of dithiothreitol or superoxide dismutase. These results suggest an inverse relationship in the regulation of 5-hydroxyindole and kynurenine pathways. The former being inhibited in the presence of high tryptophan concentration while the latter is enhanced. Furthermore, a high intracellular thiol-disulphide ratio appears to favour serotonin formation, whereas a highly reducing environment decreases kynurenine production.
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
January 1976,
Monographs in neural sciences,
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
July 1978,
Journal of neurochemistry,
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
August 1959,
A.M.A. archives of internal medicine,
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
October 2013,
Molecular neurobiology,
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
June 1979,
Naunyn-Schmiedeberg's archives of pharmacology,
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
January 1978,
Acta vitaminologica et enzymologica,
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
June 1965,
Journal of neurochemistry,
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
August 1967,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
July 1974,
Clinical chemistry,
V Rizza, and
E Bousquet, and
F Guerrera, and
M De Regis
April 1973,
Das Deutsche Gesundheitswesen,
