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Serum 1,25(OH)2D and factors related to its production were studied in 39 patients with various degrees of renal insufficiency. Serum 1,25(OH)2D levels correlated positively with 1/serum creatinine values (r = 0.54, P less than 0.001) and negatively with serum phosphorus (r = -0.39, P less than 0.02) and age (r = -0.33, P less than 0.05). There was no significant correlation between 1,25(OH)2D levels and serum calcium or calcitonin or PTH, although the logarithm of PTH correlated inversely with 1,25(OH)2D levels (r = -0.47, P less than 0.01). Patients who had normal or supranormal 1,25(OH)2D levels despite low GFR tended to have low serum phosphorus values. Serum levels of bone Gla protein (BGP), a biochemical marker for bone metabolism, correlated negatively with 1/serum creatinine (r = -0.39, P less than 0.02) and positively with PTH (r = 0.57, P less than 0.001) and age (r = 0.33, P less than 0.05). Prophylaxis with 1,25(OH)2D should be considered in patients with significantly decreased serum 1,25(OH)2D levels, as seem to occur when serum creatinine is greater than 4.0 mg/dl. However, despite the statistically significant correlation between serum 1,25(OH)2D and 1/serum creatinine, direct measurement should be used to ascertain the serum concentration of 1,25(OH)2D in chronic renal insufficiency.
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
September 1996,
The Tohoku journal of experimental medicine,
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
December 1987,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
September 2023,
Environmental science and pollution research international,
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
October 1993,
Journal of the American Society of Nephrology : JASN,
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
June 1992,
The American journal of physiology,
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
June 1985,
The New England journal of medicine,
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
March 1984,
The American journal of physiology,
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
January 1995,
Mineral and electrolyte metabolism,
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
January 1988,
Pediatric nephrology (Berlin, Germany),
A K Cheung, and
S C Manolagas, and
B D Catherwood, and
C A Mosely, and
J A Mitas, and
R C Blantz, and
L J Deftos
October 2019,
Atherosclerosis,
