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Alternative splicing of RNA transcripts from the calcitonin gene produces mRNAs that encode different polypeptides. While the mRNA encoding calcitonin predominates in thyroidal 'C' cells, calcitonin gene-related peptide (CGRP) mRNA appears to be the major mRNA component in non-thyroid tissue, including brain. The predicted peptide arising from translation of CGRP mRNA has now been identified immunocytochemically throughout the central and peripheral nervous systems. CGRP, a 37-residue peptide, is distributed in brain pathways subserving sensory, motor and autonomic functions. We report here that CGRP acts in the central nervous system to stimulate selectively noradrenergic sympathetic outflow.
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
April 1993,
Japanese journal of pharmacology,
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
January 1990,
Endocrinologie,
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
February 1991,
Bone and mineral,
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
June 1992,
Hypertension (Dallas, Tex. : 1979),
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
December 1990,
The American journal of physiology,
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
June 1986,
The Journal of pharmacology and experimental therapeutics,
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
November 1988,
Experimental eye research,
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
January 1989,
Sheng li ke xue jin zhan [Progress in physiology],
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
March 1991,
BMJ (Clinical research ed.),
L A Fisher, and
D O Kikkawa, and
J E Rivier, and
S G Amara, and
R M Evans, and
M G Rosenfeld, and
W W Vale, and
M R Brown
January 2000,
Nihon rinsho. Japanese journal of clinical medicine,
