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Contrast-enhancing agents for demonstrating abnormalities of the blood-brain barrier may extend the diagnostic utility of proton nuclear magnetic resonance (NMR) imaging. "TES," a nitroxide stable free radical derivative, was tested as a central nervous system contrast enhancer in dogs with experimentally induced unilateral cerebritis or radiation cerebral damage. After intravenous injection of TES, the normal brain showed no change in NMR appearance, but areas of disease demonstrated a dramatic increase (up to 45%) in spin-echo intensity and a decrease in T1 relaxation times. The areas of disease defined by TES enhancement were either not evident on the nonenhanced NMR images or were better defined after contrast administration. In-depth tests of toxicity, stability, and metabolism of this promising NMR contrast agent are now in progress.
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
October 1983,
Seminars in nuclear medicine,
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
June 1994,
Investigative radiology,
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
August 1989,
Journal of the American College of Cardiology,
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
November 1988,
Drug design and delivery,
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
February 1985,
Science (New York, N.Y.),
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
January 1986,
American journal of physiologic imaging,
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
February 2020,
Nanoscale,
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
March 1983,
The Practitioner,
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
September 1982,
No to shinkei = Brain and nerve,
R C Brasch, and
D E Nitecki, and
M Brant-Zawadzki, and
D R Enzmann, and
G E Wesbey, and
T N Tozer, and
L D Tuck, and
C E Cann, and
J R Fike, and
P Sheldon
May 1989,
Investigative radiology,
